Lung Cancer Cell Lines

Small cell lung cancer project site navigation project documentation data downloads.

Lung cancer cell lines.

Lymph node 3b adenocarcinoma. Doctors believe smoking causes lung cancer by damaging the cells that line the lungs. Browse squamous cell adenocarcinoma sclc and nsclc cell lines for drug response toxicology in vitro models including a549 nci h292 and more. Non small cell lung cancer is an umbrella term for several types of lung cancers.

1 3 despite response rates of 60 to 65. When you inhale cigarette smoke which is full of cancer causing substances carcinogens changes in the lung tissue begin almost immediately. Name tissue cell type disease oganism age ethnicity genes expressed crl 5844 nci h838 h838 lung. Cancer cell lines with mutant kras genes the heterogeneity of human cancers is a major obstacle to developing therapies.

Successful cell lines were evaluated for the ability to produce orthotopic lung tumors in immunocompetent hosts. Atcc provides both primary and htert immortalized bronchial epithelial cells and small airway cells that may be used side by side with nsclc or sclc cells as normal controls. Although human lung tumor derived cell lines play an important role in the investigation of lung cancer biology and genetics there is no comprehensive study comparing the genotypic and phenotypic properties of lung cancer cell lines with those of the individual tumors from which they were derived. Through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58 year old caucasian male.

Standard of care first line treatment for extensive stage small cell lung cancer is platinum chemotherapy carboplatin or cisplatin with etoposide. The cells are used as models for the study of lung cancer and the development of drug therapies against it. Lung cancer and normal cell lines atcc no. Physiologically relevant controls.

All experiments should include physiologically relevant controls. Select lung cancer cell lines authenticated by ecacc based on associated mutations and diagnosis classifications. One way of dealing with that heterogeneity is to test large numbers of patient derived cell lines for common vulnerabilities. We produced six murine lung cancer lines capable of orthotopic lung tumor formation in immunocompetent c57bl 6 animals.

Non small cell lung cancer. A549 cells are adenocarcinomic human alveolar basal epithelial cells and constitute a cell line that was first developed in 1972 by d. Once tumors demonstrated growth in a non self host cell lines were established. We compared a variety of properties of 12 human non small cell lung carcinoma nsclc cell lines.